Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

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FIG. 1.
FIG. 1.

Pancreas, β-cell, and α-cell mass. A: Mean pancreatic weight. *P < 0.05 DM-I vs. DM. B: Pancreatic fractional insulin area. ***P < 0.0001 DM-I vs. DM, **P < 0.001 DM vs. ND. C: β-Cell diameter. *P < 0.05 DM-I vs. DM. D: β-Cell mass. ^P < 0.01 DM-I vs. DM, *P < 0.05 DM-I vs. ND, *P < 0.05 DM vs. ND. E: Pancreatic fractional glucagon area. ***P < 0.0001 DM-I vs. DM and ND. F: α-Cell diameter. ^P < 0.01 DM-I vs. DM, #P < 0.005 DM-I vs. ND. G: α-Cell mass. ^P < 0.01 DM-I vs. DM. *P < 0.05 DM-I vs. ND. Pancreatic weight was 40% increased in DM-I compared with DM (P < 0.05). β-Cell mass was decreased in DM compared with ND but was approximately sixfold increased in DM-I compared with DM. α-Cell mass was comparable in DM and ND but was approximately fivefold increased in DM-I compared with DM. The increase in β-cell and α-cell mass with incretin treatment was predominantly due to endocrine hyperplasia rather than hypertrophy.

This Article

  1. Diabetes vol. 62 no. 7 2595-2604
  1. Free via Open Access: OA
  2. Supplementary Data