Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

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FIG. 3.
FIG. 3.

Distribution of α-cells and β-cells in relation to ducts in DM-I donors. Serial adjacent sections of pancreas from DM-I donors (case 6189, exenatide; 6185, sitagliptin) were immunostained for glucagon (A and C) or insulin (B and D) with hematoxylin counterstain. These serial sections indicate that the exuberant endocrine growth associated with ducts is predominantly comprised of glucagon immunoreactive cells. The percentage of glucagon-positive cells in ducts (E) and insulin-positive cells in ducts (F) is shown. The percentage of glucagon-positive cells in ducts was increased in the DM-I group compared with the DM and ND groups (*P < 0.05). In contrast, the percentage of insulin-positive cells in ducts was unchanged in the DM-I group.

This Article

  1. Diabetes vol. 62 no. 7 2595-2604
  1. Free via Open Access: OA
  2. Supplementary Data