Distribution of α-cells and β-cells in relation to ducts in DM-I donors. Serial adjacent sections of pancreas from DM-I donors
(case 6189, exenatide; 6185, sitagliptin) were immunostained for glucagon (A and C) or insulin (B and D) with hematoxylin counterstain. These serial sections indicate that the exuberant endocrine growth associated with ducts
is predominantly comprised of glucagon immunoreactive cells. The percentage of glucagon-positive cells in ducts (E) and insulin-positive cells in ducts (F) is shown. The percentage of glucagon-positive cells in ducts was increased in the DM-I group compared with the DM and ND
groups (*P < 0.05). In contrast, the percentage of insulin-positive cells in ducts was unchanged in the DM-I group.