Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

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FIG. 4.
FIG. 4.

Evidence for a direct role of GLP-1 mimetic action in α-cell hyperplasia. Images of pancreatic sections (A–F) are provided to illustrate a similar pattern of α-cell hyperplasia in the donor treated with exenatide (6189) as in the sitagliptin-treated donors, implying a role for GLP-1 action independent of DPP-4 inhibition in α-cell hyperplasia. Enlarged and often eccentrically shaped islets are apparent, as well as increased numbers of glucagon immunoreactive cells associated with and surrounding ductal structures.

This Article

  1. Diabetes vol. 62 no. 7 2595-2604
  1. Free via Open Access: OA
  2. Supplementary Data