Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia
and the Potential for Glucagon-Producing Neuroendocrine Tumors
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Pancreatic glucagon expressing neuroendocrine tumor and microadenoma. Grossly visible lesion (A) and corresponding section stained with hematoxylin and eosin (B) of the clinically undetected glucagon-expressing neuroendocrine tumor in the pancreas of a DM-I donor (nPOD case 6185) after
sitagliptin therapy. Gross specimen (C) and corresponding hematoxylin and eosin–stained section (D) of a glucagon-expressing microadenoma in nPOD case 6206, DM after sitagliptin therapy. The inset shows high-power view of representative cells stained for glucagon by immunohistochemistry. (See Supplementary Fig. 3 for an additional image of microadenoma in case 6206.)