Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

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FIG. 6.
FIG. 6.

Insulin and glucagon coexpression. Co-immunofluorescent images of islets from case 6185, sitagliptin (A–H) show endocrine cells coexpressing insulin (green) (A and E), glucagon (red) (B and F), and merged (D and H). The proportion of endocrine cells per islet that were thus detected as coexpressing insulin and glucagon was markedly increased in DM-I. Confocal images are shown of an islet from case 6185 stained for insulin (green) (I) and glucagon (red) (J), and a merged image (K) shows a mixture of cells, some expressing insulin or glucagon only (arrowheads) and some showing coexpression (arrows). DAPI nuclear counterstain (blue).

This Article

  1. Diabetes vol. 62 no. 7 2595-2604
  1. Free via Open Access: OA
  2. Supplementary Data