ON NO—The Continuing Story of Nitric Oxide, Diabetes, and Cardiovascular Disease
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Simplistic picture of the insulin-signaling path and its involvement in endothelial dysfunction highlights the crucial role
of arginine and NO. It is important to underline that the actions of insulin are dual—insulin acts after binding to its receptor
and activates both phosphatidylinositol 3-kinase (PI-3-K) and mitogen-activated protein kinase (MAPK).