Adipose Tissue Macrophages Are Innate to the Immunological Awareness of Adipose Tissue

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FIG. 1.
FIG. 1.

Hypothetical model of macrophage–T-cell interactions in adipose tissue during obesity. Diet-induced obesity upregulates MHC-II expression on ATMs, which process the antigens (Ag) and present them to CD4 cells via MHC-TCR interaction. Obesity-induced upregulation of costimulatory molecules (CD80/86) on ATMs and interaction with the T-cell CD28 molecule sustains effector T-cell proliferation. The obesity-induced antigen-specific immune response upregulates T-cell–derived Thelper1 (Th1) cytokines IL-2 and interferon-γ (IFN-γ). IL-2 in concert with other adipokines, such as leptin, may promote T-cell proliferation, whereas IFN-γ can induce macrophage activation and act on adipocytes to induce effector immune response in adipose tissue.

This Article

  1. Diabetes vol. 62 no. 8 2656-2658
  1. Free via Open Access: OA