Frail HDLs and Stiff Arteries in Type 2 Diabetes in Juveniles

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FIG. 1.
FIG. 1.

Structural and compositional heterogeneity of HDL. HDLs are macromolecular complexes containing >80 proteins and peptides, hundreds of diverse lipid species, and transporting microRNA (miRNA). This structural complexity gives rise to considerable heterogeneity with respect to size, shape, density, and charge. AP, antiplasmin; AT, antitrypsin; CETP, cholesteryl ester transfer protein; Coe, ceruloplasmin; Fib, fibrinogen; GPx, glutathione peroxidase; Hb, hemoglobin; Hp, haptoglobin; hPBP, human phosphatidylethanolamine; HRP, haptoglobin-related protein; HS-GP, HS-glycoprotein (fetuin A); LBP, lipopolysaccharide-binding protein; LCAT, lectin-cholesterol acyltransferase; Lp-PLA2, lipoprotein-associated phospholipase A2; MPO, myeloperoxidase; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, proteinase inhibitor; PIns, phosphatidylinositol; PLTP, phospholipid transfer protein; PS, phosphatidylserine; SAA, serum amyloid A; S1P, sphingosine 1-phosphate.

This Article

  1. Diabetes vol. 62 no. 8 2662-2664
  1. Free via Open Access: OA