NOx FSR in the basal and the clamp periods in the subjects selected by age (elderly vs. young) (A), by presence or absence of hypertension (HT) vs. normotensive control subjects (NTc) (B) and of hypercholesterolemia (HC) or normocholesterolemia (NCc) (C), and by T2DM (T2) vs. nondiabetic control subjects (NDc) (D). The significance values reported indicate an overall difference between test group and control subjects by the two-way
ANOVA for repeated measurements (either group or interaction effect). The P values for significant differences between the clamp and the basal values, by the two-way ANOVA for repeated measurements
(treatment effect), are also reported.