Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks
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Exercise capacity in rats bred for LRT and HRT. Exercise capacity (m) was measured using an incremental treadmill running
test to exhaustion in (A) sedentary rats at 10 and 20 weeks of age and in (B) a separate group of age-matched trained rats before (pretraining) and after (posttraining) 8 weeks (3 days/week) of treadmill
running exercise. C: Exercise response was calculated as the difference in exercise capacity before and after exercise training (exercise-trained)
for each rat. The change in exercise capacity between 10 and 20 weeks of age is shown for animals in the control group (sedentary).
*P < 0.05 for phenotype main effect; ^P < 0.05 for exercise main effect; °P < 0.05 for phenotype–exercise interaction by two-way ANOVA. P values obtained by Tukey post hoc testing are shown. n = 10–12/group.