Resistance to Aerobic Exercise Training Causes Metabolic Dysfunction and Reveals Novel Exercise-Regulated Signaling Networks

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FIG. 5.
FIG. 5.

Hyperphosphorylation of CaMKII, SMAD2, and MAPK in LRT. A–E: Phosphorylation of proteins involved in calcium, MAPK, and TGF-β MAPK signaling were measured by Western blotting in lysates from gastrocnemius muscle under resting conditions (basal) or immediately after an acute bout of exercise (exercise). ERK, extracellular signal–regulated kinase; P38, p38 mitogen-activated protein kinase; SMAD, mothers against decapentaplegic homolog. n = 6–7/group. *P < 0.05 for phenotype main effect; ^P < 0.05 for exercise main effect; °P < 0.05 for phenotype–exercise interaction by 2-way ANOVA. P values obtained by Tukey post hoc testing are displayed. AU, arbitrary units.

This Article

  1. Diabetes vol. 62 no. 8 2717-2727