Klf3−/− mice are protected from diet-induced glucose intolerance and insulin resistance. A: Glucose tolerance test (2 g glucose/kg) in mice fasted for 15 h. Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, Klf3+/+ vs. Klf3−/− ; #P < 0.05, ##P < 0.01, chow vs. high-fat diet (n = 7–19). B: Area under the curve for glucose tolerance test. *Effect of genotype. #Effect of diet. *P < 0.05, ***P < 0.001, Klf3+/+ vs. Klf3−/− ; ##P < 0.001 chow vs. high-fat diet (n = 7–19). C: Change in blood glucose levels during an insulin tolerance test (0.5 units insulin/kg) in mice fasted for 4 h (n = 8–17). D: Insulin resistance index calculated from fasting plasma insulin and blood glucose levels. Data are means ± SEM. *P < 0.05, chow-fed Klf3+/+ vs. high-fat diet–fed Klf3+/+.