Microphthalmia Transcription Factor Regulates Pancreatic β-Cell Function

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FIG. 4.
FIG. 4.

Twelve-week-old Mitfce/ce mice show no obvious differences in the expression pattern of markers characteristic for functional β-cells when analyzed by immunohistochemistry. A and B: Pax6 (green) and insulin (red). C and D: Pdx1 (green) and insulin (red). E and F: MafA (green) and insulin (red). G and H: Nkx6.1 (green) and insulin (red). I and J: GLUT2 (green) and insulin (red). KO: Quantitative RT-PCR analysis of expression of Pax6, Pdx1, MafA, Nkx6.1, and GLUT2 in mutant (Mitfce/ce) and wild-type (wt/het) islets; n > 5 per genotype. t test, *P < 0.05, **P < 0.001. INS, insulin.

This Article

  1. Diabetes vol. 62 no. 8 2834-2842