Improvement in β-Cell Secretory Capacity After Human Islet Transplantation According to the CIT07 Protocol

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FIG. 1.
FIG. 1.

Plasma insulin (A and C) and C-peptide (B and D) levels in response to bolus injections of arginine (arrows) administered under fasting and 230 mg/dL hyperglycemic clamp conditions at day 90 posttransplantation in the Edmonton protocol subjects (A and B) and at day 75 posttransplantation in the CIT07 (C, D) protocol subjects. The Edmonton cohort underwent islet transplantation between 2002 and 2003, and the CIT07 cohort underwent islet transplantation between 2008 and 2012. The C-peptide (4) and insulin (11) data for the Edmonton group previously have been reported. The gray shaded area gives the 95% CI for levels in the normal control group.

This Article

  1. Diabetes vol. 62 no. 8 2890-2897