PKCδ Impaired Vessel Formation and Angiogenic Factor Expression in Diabetic Ischemic Limbs

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FIG. 6.
FIG. 6.

mRNA expression of angiogenic factors. Quantitative real-time PCR of VEGF (A), PDGF (B), KDR/Flk-1 (C), PDGFR-β (D), eNOS (E), FGF-2 (F), and SDF-1 (G) mRNA expression and nuclear transcriptional factor activity of HIF-1α (H) in ischemic adductor muscles of nondiabetic (NDM, □) and diabetic (DM, ■) Prkcd+/+ and Prkcd−/− mice. Results are shown as mean ± SD of six to seven mice. *P = 0.05 vs. NDM Prkcd+/+, **P < 0.01 vs. NDM Prkcd+/+, †P < 0.05 vs. DM Prkcd+/+.

This Article

  1. Diabetes vol. 62 no. 8 2948-2957