Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats

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FIG. 2.
FIG. 2.

Plasma hormone levels during hyperinsulinemic hypoglycemic clamp experiments (vehicle or 1,500 nmol/kg/h SSTR2a and 20–50 mU/kg/min insulin) and corresponding AUCs. A: Effect of SSTR2a on glucagon response. B: Effect of SSTR2a on corticosterone response. C: Effect of SSTR2a on epinephrine response. D: Plasma SST levels. ■, n = 8; □, n = 8; ●, n = 6; ○, n = 5. AUCs were calculated using Prism software (GraphPad Software, San Diego, CA). Filled bars, n = 8; open bars, n = 8; vertically striped bars, n = 6; horizontally striped bars, n = 5. Data are presented as means ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05. IV, intravenous.

This Article

  1. Diabetes vol. 62 no. 8 2968-2977