Plasma hormone levels during hyperinsulinemic hypoglycemic clamp experiments (vehicle or 1,500 nmol/kg/h SSTR2a and 20–50
mU/kg/min insulin) and corresponding AUCs. A: Effect of SSTR2a on glucagon response. B: Effect of SSTR2a on corticosterone response. C: Effect of SSTR2a on epinephrine response. D: Plasma SST levels. ■, n = 8; □, n = 8; ●, n = 6; ○, n = 5. AUCs were calculated using Prism software (GraphPad Software, San Diego, CA). Filled bars, n = 8; open bars, n = 8; vertically striped bars, n = 6; horizontally striped bars, n = 5. Data are presented as means ± SEM. ***P < 0.001, **P < 0.01, *P < 0.05. IV, intravenous.