Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats

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FIG. 3.
FIG. 3.

Whole pancreatic protein contents of glucagon and SST. A: Nondiabetic and diabetic BBDP rats (with and without insulin pellet implants) that have not undergone clamp experiments. Filled bars, n = 6; open bars, n = 6; horizontally striped bars, n = 5. B: Pancreases were obtained immediately after the hyperinsulinemic hypoglycemic clamp experiments. Diabetic BBDP rats had been treated with insulin pellet implants before the clamp experiments. Filled bars, n = 8; open bars, n = 8; vertically striped bars, n = 6; horizontally striped bars, n = 5. Data are presented as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.

This Article

  1. Diabetes vol. 62 no. 8 2968-2977