Comment on: Korpos et al. The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human. Diabetes 2013;62:531–542
- Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
- Corresponding author: Charmaine J. Simeonovic, .
Korpos et al. (1) claim that “limited information exists on the nature of the ECM [extracellular matrix] of the pancreas and, in particular, on the composition of peri-islet capsule,” and that they provide the “the first comprehensive analysis of the [ECM] composition of peri-islet capsules.”
We dispute the strength of these claims. In mice we originally reported in 2008 that a basement membrane (BM) exists around islets, and eight unique components were identified (type IV collagens α1, α2, laminin …