Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes

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FIG. 1.
FIG. 1.

Duodenal lipid-sensing mechanisms. Upon intake of nutrients, the duodenum activates a complex molecular and neuronal network to lower hepatic glucose production. High-fat feeding induces duodenal CCK resistance and direct activation of PKA bypasses the defect. High-fat feeding induces obesogenic microbiota and subequently alters CCK action. AC, adenylyl cyclase; CCK1-R, CCK receptor; HFD, high-fat diet.

This Article

  1. Diabetes vol. 62 no. 9 3005-3013