Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes

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FIG. 2.
FIG. 2.

Jejunal nutrient-sensing mechanisms. An influx of nutrients into the duodenum or jejunum activates a complex biochemical, molecular, neuronal, and physiological network to lower hepatic glucose production. Although there are some parallels regarding nutrient sensing in the duodenum and jejunum, it appears that unlike in the duodenum, jejunal nutrient sensing is PKA independent. ACS, acyl-CoA synthetase; NTS NMDA, nucleus of the solitary tract N-methyl-d-aspartate; PYY, peptide YY.

This Article

  1. Diabetes vol. 62 no. 9 3005-3013