Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

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FIG. 1.
FIG. 1.

Whole-body phenotype of IL-18R−/− mice. A: Growth curves during chow and HFD (CON-chow: n = 21; CON-HFD: n = 12; IL-18R−/−-chow: n = 14; IL-18R−/−-HFD: n = 14). B: Fat percentage during chow and HFD (CON-chow: n = 19; CON-HFD: n = 19; IL-18R−/−-chow: n = 12; IL-18R−/−-HFD: n = 11). C: Inguinal, gonadal, and retroperitoneal fat pads during chow diet (CON = 13; IL-18R−/−: n = 7). D: Inguinal, gonadal, and retroperitoneal fat pads during HFD (CON = 11; IL-18R−/−: n = 10). Average 24-h food intake (E) and Vo2 (F) during 2 days of chow and HFD and RER during 3 days of ad libitum feeding, 24-h fasting, and 24-h refeeding of chow (G) and HFD (F) obtained from control (black bars) and IL-18R−/− (gray bars) male mice at 7 months of age mice (CON-chow: n = 7; CON-HFD: n = 8; IL-18R−/−-chow: n = 8; IL-18R−/−-HFD: n = 6). Results are presented as mean ± SEM. *P < 0.05 vs. controls. CON, control; KO, knockout; Retro, retroperitoneal; WT, wild-type.

This Article

  1. Diabetes vol. 62 no. 9 3064-3074