IL-18R−/− mice develop hyperlipidemia and inflammation on a chow diet but not on an HFD. A: Triglycerides in muscle (CON-chow: n = 17; CON-HFD: n = 9; IL-18R−/−-chow: n = 8; IL-18R−/−-HFD: n = 5). B: Representative immunoblot and densitometric quantification of JNK1/2 phosphorylation in soleus muscle (n = 7–8). C: Triglycerides in liver (n = 5–8). D: Representative immunoblot and densitometric quantification of JNK1/2 phosphorylation in liver (n = 6–8). mRNA levels of SREBP1c (E) in liver (n = 9–19) and mRNA levels of FAS (F) in liver (n = 9–19) during chow and HFD obtained from control (black bars) and IL-18R−/− (gray bars) male mice at 7 months of age. Results are presented as mean ± SEM. *P < 0.05 vs. control. #P < 0.05 vs. chow diet. CON, control; pJNK, phosphorylated JNK; SREBP1c, sterol regulatory–element binding protein-1c.