Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

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FIG. 4.
FIG. 4.

IL-18R−/− mice exhibit blunted phosphorylation of ACCβ in muscle, liver, and adipose tissue. Representative immunoblot and densitometric quantification (A) of ACCβ phosphorylation in soleus muscle (n = 7–8), representative immunoblot and densitometric quantification (B) of ACCβ phosphorylation in liver (n = 5–8), and representative immunoblot and densitometric quantification (C) of ACCβ phosphorylation in adipose tissue (n = 6–10) during chow and HFD obtained from control (black bars) and IL-18R−/− (gray bars) male mice at 7 months of age. Results are presented as mean ± SEM. *P < 0.05 vs. control; #P < 0.05 vs. chow diet. CON, control; pACC, phosphorylated ACC.

This Article

  1. Diabetes vol. 62 no. 9 3064-3074