Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

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FIG. 6.
FIG. 6.

Mice overexpressing IL-18 in skeletal muscle are protected from diet-induced obesity. Densitometric quantification of IL-18 protein (A) in the tibialis anterior muscle after DNA electrotransfer of 1 μg, 10 μg, and 20 μg plasmid (n = 6/dose), growth curves (B; n = 6–10), fat percentage (C; n = 6–10), and image of mice overexpressing IL-18 (D) in the tibialis anterior muscle (filled bars) after 4 weeks of an HFD compared with mice overexpressing an empty vector (open bars). Results are presented as mean ± SEM. *P < 0.05 vs. empty vector. Con, control; NS, not significant.

This Article

  1. Diabetes vol. 62 no. 9 3064-3074