Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

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FIG. 7.
FIG. 7.

Mice overexpressing IL-18 in skeletal muscle have enhanced AMPK signaling. AMPKα1 (A) activity (n = 6/group), representative immunoblot and densitometric quantification of ACCβ (B) phosphorylation (n = 6/group), mRNA levels (C) of β-hydroxyacyl-CoA-dehydrogenase (β-HAD) (n = 8/group), and mRNA levels (D) of CPT1β (n = 7/group) in the muscle overexpressing IL-18 (filled bars) compared with a muscle electroporated with an empty vector (open bars). Results are presented as mean ± SEM. *P < 0.05 vs. empty vector. pACC, phosphorylated ACC; RB, reactive brown was used as loading control; Ctr, control.

This Article

  1. Diabetes vol. 62 no. 9 3064-3074