Plasminogen Activator Inhibitor-1 Is Involved in Streptozotocin-Induced Bone Loss in Female Mice

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FIG. 4.
FIG. 4.

Effects of PAI-1 deficiency on bone resorption in tibia of both sexes of diabetic mice. TRAP staining (A) and number of TRAP-positive multinucleated cells (B) in tibia of control and streptozotocin-treated male PAI-1 WT and KO mice. Results are expressed as means ± SEM. *P < 0.05 (n = 5–7 in each group). Levels of RANKL mRNA (C) in tibia of control and streptozotocin-treated male PAI-1 WT and KO mice. Results are expressed relative to β-actin mRNA values and expressed as means ± SEM. *P < 0.05 (n = 5–7 in each group). TRAP staining (D) and number of TRAP-positive multinucleated cells (E) in tibia of control and streptozotocin-treated female PAI-1 WT and KO mice. Results are expressed as means ± SEM. *P < 0.05 (n = 5–7 in each group). Levels of RANKL mRNA (F) in tibia of control and streptozotocin-treated female PAI-1 WT and KO mice. Results are expressed relative to β-actin mRNA values and expressed as means ± SEM. *P < 0.05 (n = 5–7 in each group). Cont, control; STZ, streptozotocin.

This Article

  1. Diabetes vol. 62 no. 9 3170-3179