Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance

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FIG. 6.
FIG. 6.

Weight cycling increases AT gene expression of T-cell markers and CD4+ Th1 and CD8+ T cell–derived cytokines. RNA was isolated from the epididymal AT and gene expression was analyzed by real-time RT-PCR. A: Cd3. B: Cd4. C: Cd8. D: Ifng. E: Il12. F: Il2. G: Il2ra. H: Il2rb. I: Ccl5. Data are presented as mean ± SEM; n = 8–14/group. Groups not connected by the same letter are significantly different; P < 0.05. HF/LF/HF, weight-cycling group; LF/HF/HF, weight-gain group; LF/LF/LF, lean control group.

This Article

  1. Diabetes vol. 62 no. 9 3180-3188