MicroRNA-24/MODY Gene Regulatory Pathway Mediates Pancreatic β-Cell Dysfunction

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FIG. 6.
FIG. 6.

Overexpression of Neurod1 or Hnf1a blocked the cellular dysfunction induced by miR-24. Successful overexpression of Neurod1 restored the Cdk4 protein level (A), followed by the recovery of the GSIS index (B), KSIS index (C), and DNA synthesis (D) (**P < 0.01 vs. Neg+myc; ##P < 0.01 vs. miR-24+myc). Overexpression of Hnf1a also helped to rescue Cdk4 protein (E) as well as to restore the GSIS index (F), KSIS index (G), and DNA synthesis (H) (*P < 0.05 or **P < 0.01 vs. Neg+Adtrack; ##P < 0.01 vs. miR-24+Adtrack).

This Article

  1. Diabetes vol. 62 no. 9 3194-3206