A: LocusZoom plot of association results and LD around BACE2. See Fig. 1 legend for details. B: Aligned genes, SNPs, active enhancer marks, OC regions, and gene expression profiles of the FCP-associated BACE2 region on chromosome 21. SNPs within BACE2 overlap with peaks representing regions enriched for active histone marks and OC regions in cell types representing eight
different tissues. BACE2 is expressed in epidermal skin, breast and colon cancers, skeletal muscle, adipose tissue, and mammary epithelial cells.
cM, genetic distance between markers; Mb, physical distance.