In This Issue of Diabetes

Edited by Helaine E. Resnick, PhD, MPH

Type 1 Diabetes Affects Brain Development in Young Children

New work in this issue of Diabetes emphasizes the unfavorable impact of type 1 diabetes (T1D) on both brain volume and cognition in young children. Because early childhood is an important period for brain development, the effects of glucose dysregulation in T1D may result in significant physiological complications as well as cognitive deficits, especially when T1D appears early. While previous research indicates that young brains are vulnerable to T1D, most studies related to the effects of T1D on brain structure have been conducted in adults and older children. New work by Marzelli et al. (p. 343) investigated the neuroanatomical correlates of dysglycemia in children with early-onset T1D. Using identical scanners, structural MRI images of the brain were obtained from 142 children with T1D and 68 age-matched control subjects. The average age of these participants was 7.0 years with an average age of T1D onset of 4.1 years of age. Voxel-based morphometry was used to examine correlations between regional brain volumes and measures of glycemic exposure as well as regional differences between groups. The children with T1D showed decreased gray matter volume (GMV) in the bilateral occipital and cerebellar regions as well as hyperglycemic exposure–related GMV decreases in the medial frontal and temporal-occipital regions. The T1D group also had increased GMV in the left inferior prefrontal, insula, and temporal pole regions, and glycemic exposure in this group was associated with increased GMV in the …

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This Article

  1. doi: 10.2337/db14-ti01 Diabetes vol. 63 no. 1 1-2
  1. Free via Open Access: OA