Short Leukocyte Telomere Length Predicts Risk of Diabetes in American Indians: the Strong Heart Family Study
- Jinying Zhao1⇑,
- Yun Zhu1,
- Jue Lin2,
- Tet Matsuguchi2,
- Elizabeth Blackburn2,
- Ying Zhang3,
- Shelley A. Cole4,
- Lyle G. Best5,
- Elisa T. Lee3 and
- Barbara V. Howard6
- 1Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA
- 2Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA
- 3Center for American Indian Health Research, University of Oklahoma Health Science Center, Oklahoma City, OK
- 4Texas Biomedical Research Institute, San Antonio, TX
- 5Missouri Breaks Industries Research Inc., Timber Lake, SD
- 6MedStar Research Institute, Hyattsville, MD
- Corresponding author: Jinying Zhao, .
Telomeres play a central role in cellular aging, and shorter telomere length has been associated with age-related disorders including diabetes. However, a causal link between telomere shortening and diabetes risk has not been established. In a well-characterized longitudinal cohort of American Indians participating in the Strong Heart Family Study, we examined whether leukocyte telomere length (LTL) at baseline predicts incident diabetes independent of known diabetes risk factors. Among 2,328 participants free of diabetes at baseline, 292 subjects developed diabetes during an average 5.5 years of follow-up. Compared with subjects in the highest quartile (longest) of LTL, those in the lowest quartile (shortest) had an almost twofold increased risk of incident diabetes (hazard ratio [HR] 1.83 [95% CI 1.26–2.66]), whereas the risk for those in the second (HR 0.87 [95% CI 0.59–1.29]) and the third (HR 0.95 [95% CI 0.65–1.38]) quartiles was statistically nonsignificant. These findings suggest a nonlinear association between LTL and incident diabetes and indicate that LTL could serve as a predictive marker for diabetes development in American Indians, who suffer from disproportionately high rates of diabetes.
This article contains Supplementary Data online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db13-0744/-/DC1.
The views expressed in this article are those of the authors and do not necessarily reflect those of the Indian Health Service.
See accompanying commentary, p. 65.
- Received May 8, 2013.
- Accepted August 9, 2013.
- © 2014 by the American Diabetes Association.
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