SLC30A8 Nonsynonymous Variant Is Associated With Recovery Following Exercise and Skeletal Muscle Size and Strength

  1. Joseph M. Devaney1
  1. 1Department of Integrative Systems Biology, Research Center for Genetic Medicine, Children’s National Medical Center, Washington, DC
  2. 2Department of Orthopedic Surgery and Sports Medicine, Children’s National Medical Center, Washington, DC
  3. 3George Washington University School of Medicine, Washington, DC
  4. 4Department of Kinesiology, University of Massachusetts, Amherst, MA
  5. 5Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT
  6. 6Center for Lifestyle Medicine and Department of Health Professions, University of Central Florida, Orlando, FL
  7. 7Laboratory for Physical Activity and Exercise Intervention Research, University of Michigan, Ann Arbor, MI
  8. 8Department of Sport Science and Health, Dublin City University, Dublin, Ireland
  9. 9School of Allied Health, University of Connecticut, Storrs, CT
  10. 10Human Performance Laboratory, Central Michigan University, Mount Pleasant, MI
  11. 11Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL
  1. Corresponding authors: Laura L. Tosi, ltosi{at}, and Joseph M. Devaney, jdevaney{at}
  1. L.L.T. and J.M.D. contributed equally to this work.


Genome-wide association studies have identified thousands of variants that are associated with numerous phenotypes. One such variant, rs13266634, a nonsynonymous single nucleotide polymorphism in the solute carrier family 30 (zinc transporter) member eight gene, is associated with a 53% increase in the risk of developing type 2 diabetes (T2D). We hypothesized that individuals with the protective allele against T2D would show a positive response to short-term and long-term resistance exercise. Two cohorts of young adults—the Eccentric Muscle Damage (EMD; n = 156) cohort and the Functional Single Nucleotide Polymorphisms Associated with Muscle Size and Strength Study (FAMuSS; n = 874)—were tested for association of the rs13266634 variant with measures of skeletal muscle response to resistance exercise. Our results were sexually dimorphic in both cohorts. Men in the EMD study with two copies of the protective allele showed less post-exercise bout strength loss, less soreness, and lower creatine kinase values. In addition, men in the FAMuSS, homozygous for the protective allele, showed higher pre-exercise strength and larger arm skeletal muscle volume, but did not show a significant difference in skeletal muscle hypertrophy or strength with resistance training.


  • Received July 24, 2013.
  • Accepted September 30, 2013.

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