In This Issue of Diabetes

Edited by Helaine E. Resnick, PhD, MPH

Type 1 Diabetes Increases as the pH of Drinking Water Decreases

New data in this issue of Diabetes (p. 632) suggest that acidic drinking water has a significant effect on gut bacteria leading to higher risk of type 1 diabetes (T1D). Nonobese diabetic (NOD) mice are frequently used as a model for T1D, and previous studies have shown that the composition of gut bacteria in these mice influences the incidence of T1D. It had been widely assumed that differences in laboratory and colony cleanliness were primary factors that lead to differences in gut microflora and ultimately to differences in T1D incidence. However, dietary factors that influence the makeup of the gut microbiome might also explain differences in T1D in this mouse model. In the new work presented here, Sofi et al. explore the possibility that the pH of drinking water impacts the gut microbiome and, in turn, T1D. Female NOD mice were maintained in pathogen-free facilities and were given autoclaved neutral (pH 7.0–7.2) water (NW) or acidic water (AW) with added HCl (pH 3.0–3.2). Mice purchased at 3–4 weeks that had been given AW since birth were continued on AW or switched to NW. The group that continued on AW developed hyperglycemia rapidly compared with the group switched to NW. In contrast, prediabetic mice purchased at 8 weeks and continued on AW did not show a difference in disease progression compared to those switched to NW. In-house NOD mice that were given AW exhibited faster onset and progression of T1D, similar to the …

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This Article

  1. doi: 10.2337/db14-ti02 Diabetes vol. 63 no. 2 379-380
  1. Free via Open Access: OA