Toward Personalized Prevention of Obesity: Can Vitamin D Negate the FTO Effect?

  1. Corinne D. Engelman
  1. Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
  1. Corresponding author: Corinne D. Engelman, cengelman{at}

According to the World Health Organization, the worldwide prevalence of childhood overweight and obesity increased from 4.2% in 1990 to 6.7% in 2010 and it is expected to reach 9.1% in 2020 (1). This is alarming because BMI in childhood is associated with type 2 diabetes, hypertension, coronary heart disease, and mortality in adulthood (2). The obesity epidemic is no longer merely a problem in developed countries, but is now affecting developing countries as well. In fact, more than 30 million overweight children are living in developing countries compared with 10 million in developed countries (3). In the U.S., the Surgeon General issued the Call to Action to Prevent and Decrease Overweight and Obesity (4) in 2001 and the reduction of overweight and obesity was an objective of Healthy People 2010 (5). However, the ensuing public health efforts to address the obesity epidemic by promoting healthy eating and physical activity have had limited success thus far, with overweight and obesity rates continuing to increase. At …

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