Insulin Resistance Compensation: Not Just a Matter of β-Cells?

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Figure 1
Figure 1

Adult β-cell mass expansion in response to increased insulin demand, such as that generated by insulin resistance, may take place based on preexisting β-cells—by enhanced β-cell replication and/or increased individual β-cell size—or new β-cells could be generated from other cell sources, such as neogenesis from ductal cells or transdifferentiation from acinar cells or α-cells. In diabetic patients, β-cell mass reduction can result from increased apoptotic cell death, and recently β-cell dedifferentiation and conversion into other endocrine non–β-cells of the islets has been described in diabetic mice.

This Article

  1. Diabetes vol. 63 no. 3 832-834
  1. Free via Open Access: OA