When the Skeleton Is Controlling Pancreatic β-Cell Mass During Development and After

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1
Figure 1

Osteoblast-secreted osteocalcin in its active (undercarboxylated) form favors insulin sensitivity in muscle, adipose tissue, and liver, having a positive action on glycemia. In the pancreas, active osteocalcin stimulates insulin release and β-cell proliferation. In β-cells, osteocalcin binds to its receptor Gprc6a, inducing the activation of cyclin D1 and cell-cycle progression leading to β-cell proliferation and increase in β-cell mass.

This Article

  1. Diabetes vol. 63 no. 3 838-840
  1. Free via Open Access: OA