Remodeling of Nutrient Homeostasis by Unfolded Protein Response
(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.
Impact of hyperinsulinemia as a consequence and cause of obesity-associated ER stress on nutrient homeostasis. Hyperinsulinemia
caused by obesity and overnutrition produces ER stress and UPR by enhancing protein biosynthesis and subsequent accumulation
of misfolded/unfolded proteins. In addition to enhanced protein biosynthesis, proteasome and autophagy are candidate targets
of insulin to induce ER stress because insulin could impair their function in the obese state. Whether UPR causes insulin
resistance or relieves ER stress remains an open question.