Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922

Boden et al. (1) reported that insulin-induced endoplasmic reticulum (ER) stress increased in subcutaneous adipose tissue of human subjects in vivo. The authors elegantly show that the induction of the unfolded protein response was not related to increased glucose metabolism or oxidative stress. The response was, however, associated with accumulation of ubiquitination-associated proteins, some of which are potential causes for ER stress. From these data, the authors conclude that they …