Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223

  1. Antonio E. Pontiroli
  1. Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy
  1. Corresponding author: Antonio E. Pontiroli, antonio.pontiroli{at}unimi.it.

The article in this issue of Diabetes by Dutia et al. (1) shows that in obese diabetic patients returning to normal glucose tolerance (NGT) after gastric bypass β-cell function appears to recover if evaluated through oral glucose tolerance test (OGTT), but not if evaluated through isoglycemic glucose clamp. In fact, the plot indicating Δinsulin/Δglucose (insulin release [IR]) versus 1/homeostasis model assessment of insulin resistance (HOMA-IR) (insulin sensitivity [IS]) grows during OGTT, but stays flat or moves right, indicating …

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