Comment on Ye et al. The Association Between Circulating Lipoprotein(a) and Type 2 Diabetes: Is It Causal? Diabetes 2014;63:332–342

  1. Hüsniye Yüksel1
  1. 1Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey
  2. 2Edirne Educational Hospital, Edirne, Turkey
  1. Corresponding author: Altan Onat, alt_onat{at}

Excess levels of lipoprotein(a) [Lp(a)] has long been recognized as a cause of coronary heart disease (CHD), though the association of Lp(a) with diabetes risk has challenged medical researchers for several reasons, mainly because the association shape is fundamentally a U-shaped one. Ye et al. (1) have newly confirmed such an inverse association in the combined sex of the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort, after the first demonstration in the Women’s …

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