Response to Comment on Ye et al. The Association Between Circulating Lipoprotein(a) and Type 2 Diabetes: Is It Causal? Diabetes 2014;63:332–342

  1. Nita G. Forouhi1
  1. 1MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, U.K.
  2. 2Department of Public Health and Primary Care, University of Cambridge, Cambridge, U.K.
  3. 3Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, U.K.
  1. Corresponding author: Zheng Ye, zheng.ye{at}mrc-epid.cam.ac.uk.

Onat et al. (1) questioned our conclusion of a noncausal inverse association between lipoprotein(a) [Lp(a)] levels and risk of type 2 diabetes (T2D) (2). We agree that autoimmune activation may play a role in the development of T2D, but how this may contribute to the pathogenesis of T2D is still unclear and needs further research in human and animal studies (3). In our work, we focused on examining …

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