On the cover: Insulitis in a 13-year-old organ donor with type 1 diabetes for 5 years (nPOD 6243). Immune cell phenotypes in insulitic islets were determined by multi-immunofluoresence. An insulitic islet is shown with a lymphocytic infiltrate consisting of both CD3+ T cells (pink) and CD20+ B cells (green). α-Cells are detected with antiglucagon antibodies (yellow). Photograph courtesy of Martha Campbell-Thompson and Ann Fu of the University of Florida. Their article, “Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes” (p. 719) and an accompanying article, “Insulitis Revisited” (p. 545), are featured in this issue of Diabetes.
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