Diabetes: 65 (7)

July 01 2016; volume 65 issue 7

In This Issue

Open Access
In This Issue of Diabetes
Diabetes 2016 Jul; 65 (7): 1755-1756. https://doi.org/10.2337/db16-ti07

Perspectives in Diabetes

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Skeletal Metabolism, Fracture Risk, and Fracture Outcomes in Type 1 and Type 2 Diabetes
Deborah E. Sellmeyer, Roberto Civitelli, Lorenz C. Hofbauer, Sundeep Khosla, Beata Lecka-Czernik and Ann V. Schwartz

Diabetes 2016 Jul; 65 (7): 1757-1766. https://doi.org/10.2337/db16-0063
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Pharmacological Targeting of the Atherogenic Dyslipidemia Complex: The Next Frontier in CVD Prevention Beyond Lowering LDL Cholesterol
Changting Xiao, Satya Dash, Cecilia Morgantini, Robert A. Hegele and Gary F. Lewis

Diabetes 2016 Jul; 65 (7): 1767-1778. https://doi.org/10.2337/db16-0046
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Illuminating the Effects of Stroke on the Diabetic Brain: Insights From Imaging Neural and Vascular Networks in Experimental Animal Models
Patrick Reeson, Andrew Jeffery and Craig E. Brown

Diabetes 2016 Jul; 65 (7): 1779-1788. https://doi.org/10.2337/db16-0064

Commentaries

Open Access
The Genetic Landscape of β-Cell Proliferation: Toward a Road Map
Bridget K. Wagner

Diabetes 2016 Jul; 65 (7): 1789-1790. https://doi.org/10.2337/dbi16-0018
Open Access
How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore
Sebastian Barg and Alenka Guček

Diabetes 2016 Jul; 65 (7): 1791-1793. https://doi.org/10.2337/dbi16-0019
Open Access
New Players in the Field of T1D: Anti-Peripherin B Lymphocytes
Peggy L. Kendall

Diabetes 2016 Jul; 65 (7): 1794-1796. https://doi.org/10.2337/dbi16-0017
Open Access
Is Sugar Addictive?
George A. Bray

Diabetes 2016 Jul; 65 (7): 1797-1799. https://doi.org/10.2337/dbi16-0022

Diabetes Symposium: Bioactive Lipids and Nonpeptide Mediators of Metabolism

This section features three articles from the 3rd Diabetes Symposium held in conjunction with the ADA's 76th Scientific Sessions in New Orleans, LA, 10–14 June 2016.
- Open Access
  De Novo Lipogenesis Products and Endogenous Lipokines
  Mustafa Yilmaz, Kathryn C. Claiborn and Gökhan S. Hotamisligil
  
  Diabetes 2016 Jul; 65 (7): 1800-1807. https://doi.org/10.2337/db16-0251
- Open Access
  GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects
  Pedro M. Moraes-Vieira, Alan Saghatelian and Barbara B. Kahn
  
  Diabetes 2016 Jul; 65 (7): 1808-1815. https://doi.org/10.2337/db16-0221
- Open Access
  RNA Regulation of Lipotoxicity and Metabolic Stress
  George Caputa and Jean E. Schaffer
  
  Diabetes 2016 Jul; 65 (7): 1816-1823. https://doi.org/10.2337/db16-0147

Metabolism

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Early Low-Fat Diet Enriched With Linolenic Acid Reduces Liver Endocannabinoid Tone and Improves Late Glycemic Control After a High-Fat Diet Challenge in Mice
Laurent Demizieux, Fabiana Piscitelli, Stephanie Troy-Fioramonti, Fabio Arturo Iannotti, Simona Borrino, Joseph Gresti, Tania Muller, Jerome Bellenger, Cristoforo Silvestri, Vincenzo Di Marzo and Pascal Degrace

Diabetes 2016 Jul; 65 (7): 1824-1837. https://doi.org/10.2337/db15-1279
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Dual Actions of Apolipoprotein A-I on Glucose-Stimulated Insulin Secretion and Insulin-Independent Peripheral Tissue Glucose Uptake Lead to Increased Heart and Skeletal Muscle Glucose Disposal
Joan Domingo-Espín, Maria Lindahl, Oktawia Nilsson-Wolanin, Samuel W. Cushman, Karin G. Stenkula and Jens O. Lagerstedt

Diabetes 2016 Jul; 65 (7): 1838-1848. https://doi.org/10.2337/db15-1493
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Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes
Sofiya Gancheva, Alessandra Bierwagen, Kirti Kaul, Christian Herder, Peter Nowotny, Sabine Kahl, Guido Giani, Birgit Klueppelholz, Birgit Knebel, Paul Begovatz, Klaus Strassburger, Hadi Al-Hasani, Jesper Lundbom, Julia Szendroedi and Michael Roden, for the German Diabetes Study (GDS) Group

Diabetes 2016 Jul; 65 (7): 1849-1857. https://doi.org/10.2337/db16-0162
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Fasting Plasma Insulin Concentrations Are Associated With Changes in Hepatic Fatty Acid Synthesis and Partitioning Prior to Changes in Liver Fat Content in Healthy Adults
Camilla Pramfalk, Michael Pavlides, Rajarshi Banerjee, Catriona A. McNeil, Stefan Neubauer, Fredrik Karpe and Leanne Hodson

Diabetes 2016 Jul; 65 (7): 1858-1867. https://doi.org/10.2337/db16-0236
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Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity
Hyeon-Ju Jeong, Hye-Jin Lee, Tuan Anh Vuong, Kyu-Sil Choi, Dahee Choi, Sung-Hoi Koo, Sung Chun Cho, Hana Cho and Jong-Sun Kang

Diabetes 2016 Jul; 65 (7): 1868-1882. https://doi.org/10.2337/db15-1500
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Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice
John R. Ussher, Natasha Fillmore, Wendy Keung, Liyan Zhang, Jun Mori, Vaninder K. Sidhu, Arata Fukushima, Keshav Gopal, David G. Lopaschuk, Cory S. Wagg, Jagdip S. Jaswal, Jason R.B. Dyck and Gary D. Lopaschuk

Diabetes 2016 Jul; 65 (7): 1883-1891. https://doi.org/10.2337/db15-1145

Signal Transduction

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Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ_1–40/42 and Phospho-Tau May Abet Alzheimer Development
Mini Sajan, Barbara Hansen, Robert Ivey III, Joshua Sajan, Csilla Ari, Shijie Song, Ursula Braun, Michael Leitges, Margaret Farese-Higgs and Robert V. Farese

Diabetes 2016 Jul; 65 (7): 1892-1903. https://doi.org/10.2337/db15-1428
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Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α
Xuqing Chen, Feifei Zhang, Qi Gong, Aoyuan Cui, Shu Zhuo, Zhimin Hu, Yamei Han, Jing Gao, Yixuan Sun, Zhengshuai Liu, Zhongnan Yang, Yingying Le, Xianfu Gao, Lily Q. Dong, Xin Gao and Yu Li

Diabetes 2016 Jul; 65 (7): 1904-1915. https://doi.org/10.2337/db15-1637
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Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes
Meghan Sauvé, Sonya K. Hui, Danny D. Dinh, Warren D. Foltz, Abdul Momen, Sergei A. Nedospasov, Stefan Offermanns, Mansoor Husain, Jeffrey T. Kroetsch, Darcy Lidington and Steffen-Sebastian Bolz

Diabetes 2016 Jul; 65 (7): 1916-1928. https://doi.org/10.2337/db15-1450

Obesity Studies

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Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents
Ania M. Jastreboff, Rajita Sinha, Jagriti Arora, Cosimo Giannini, Jessica Kubat, Saima Malik, Michelle A. Van Name, Nicola Santoro, Mary Savoye, Elvira J. Duran, Bridget Pierpont, Gary Cline, R. Todd Constable, Robert S. Sherwin and Sonia Caprio

Diabetes 2016 Jul; 65 (7): 1929-1939. https://doi.org/10.2337/db15-1216

Islet Studies

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Amelioration of Diabetes by Protein S
Taro Yasuma, Yutaka Yano, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Paloma Gil-Bernabe, Tetsu Kobayashi, Kota Nishihama, Josephine A. Hinneh, Rumi Mifuji-Moroka, Ziaurahman Roeen, John Morser, Isaac Cann, Motoh Iwasa, Yoshiyuki Takei and Esteban C. Gabazza

Diabetes 2016 Jul; 65 (7): 1940-1951. https://doi.org/10.2337/db15-1404
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Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion
Stephan C. Collins, Hyun Woong Do, Benoit Hastoy, Alison Hugill, Julie Adam, Margarita V. Chibalina, Juris Galvanovskis, Mahdieh Godazgar, Sheena Lee, Michelle Goldsworthy, Albert Salehi, Andrei I. Tarasov, Anders H. Rosengren, Roger Cox and Patrik Rorsman

Diabetes 2016 Jul; 65 (7): 1952-1961. https://doi.org/10.2337/db15-1489
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Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells
Subhankar Dolai, Li Xie, Dan Zhu, Tao Liang, Tairan Qin, Huanli Xie, Youhou Kang, Edwin R. Chapman and Herbert Y. Gaisano

Diabetes 2016 Jul; 65 (7): 1962-1976. https://doi.org/10.2337/db15-1436

Immunology and Transplantation

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B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice
Caroline M. Leeth, Jeremy Racine, Harold D. Chapman, Berta Arpa, Jorge Carrillo, Jorge Carrascal, Qiming Wang, Jeremy Ratiu, Leire Egia-Mendikute, Estela Rosell-Mases, Thomas Stratmann, Joan Verdaguer and David V. Serreze

Diabetes 2016 Jul; 65 (7): 1977-1987. https://doi.org/10.2337/db15-1606

Pathophysiology

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Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
Helena Elding Larsson, Kendra Vehik, Michael J. Haller, Xiang Liu, Beena Akolkar, William Hagopian, Jeffrey Krischer, Åke Lernmark, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G. Ziegler and Marian Rewers, for the TEDDY Study Group

Diabetes 2016 Jul; 65 (7): 1988-1995. https://doi.org/10.2337/db15-1180
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Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice
Keiji Tanigaki, Ken L. Chambliss, Ivan S. Yuhanna, Anastasia Sacharidou, Mohamed Ahmed, Dmitriy N. Atochin, Paul L. Huang, Philip W. Shaul and Chieko Mineo

Diabetes 2016 Jul; 65 (7): 1996-2005. https://doi.org/10.2337/db15-1605

Complications

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Mast Cells Regulate Wound Healing in Diabetes
Ana Tellechea, Ermelindo C. Leal, Antonios Kafanas, Michael E. Auster, Sarada Kuchibhotla, Yana Ostrovsky, Francesco Tecilazich, Dimitrios Baltzis, Yongjun Zheng, Eugénia Carvalho, Janice M. Zabolotny, Zuyi Weng, Anastasia Petra, Arti Patel, Smaro Panagiotidou, Leena Pradhan-Nabzdyk, Theoharis C. Theoharides and Aristidis Veves

Diabetes 2016 Jul; 65 (7): 2006-2019. https://doi.org/10.2337/db15-0340
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microRNA-182 Mediates Sirt1-Induced Diabetic Corneal Nerve Regeneration
Ye Wang, Xiaowen Zhao, Xiaoming Wu, Yunhai Dai, Peng Chen and Lixin Xie

Diabetes 2016 Jul; 65 (7): 2020-2031. https://doi.org/10.2337/db15-1283

Pharmacology and Therapeutics

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Empagliflozin, via Switching Metabolism Toward Lipid Utilization, Moderately Increases LDL Cholesterol Levels Through Reduced LDL Catabolism
François Briand, Eric Mayoux, Emmanuel Brousseau, Noémie Burr, Isabelle Urbain, Clément Costard, Michael Mark and Thierry Sulpice

Diabetes 2016 Jul; 65 (7): 2032-2038. https://doi.org/10.2337/db16-0049

Genetics/Genomes/Proteomics/Metabolomics

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Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth
Denise M. Scholtens, James R. Bain, Anna C. Reisetter, Michael J. Muehlbauer, Michael Nodzenski, Robert D. Stevens, Olga Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard and William L. Lowe, Jr., for the HAPO Study Cooperative Research Group

Diabetes 2016 Jul; 65 (7): 2039-2050. https://doi.org/10.2337/db15-1748
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Discovery of a Genetic Metabolic Cause for Mauriac Syndrome in Type 1 Diabetes
Michael J. MacDonald, Noaman M. Hasan, Israr-ul H. Ansari, Melissa J. Longacre, Mindy A. Kendrick and Scott W. Stoker

Diabetes 2016 Jul; 65 (7): 2051-2059. https://doi.org/10.2337/db16-0099
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New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins
Delnaz Roshandel, Ronald Klein, Barbara E.K. Klein, Bruce H.R. Wolffenbuttel, Melanie M. van der Klauw, Jana V. van Vliet-Ostaptchouk, Gil Atzmon, Danny Ben-Avraham, Jill P. Crandall, Nir Barzilai, Shelley B. Bull, Angelo J. Canty, S. Mohsen Hosseini, Linda T. Hiraki, John Maynard, David R. Sell, Vincent M. Monnier, Patricia A. Cleary, Barbara H. Braffett, the DCCT/EDIC Research Group and Andrew D. Paterson

Diabetes 2016 Jul; 65 (7): 2060-2071. https://doi.org/10.2337/db15-1484
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Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium
Nicholette D. Palmer, Lynne E. Wagenknecht, Carl D. Langefeld, Nan Wang, Thomas A. Buchanan, Anny H. Xiang, Hooman Allayee, Richard N. Bergman, Leslie J. Raffel, Yii-Der Ida Chen, Talin Haritunians, Tasha Fingerlin, Mark O. Goodarzi, Kent D. Taylor, Jerome I. Rotter, Richard M. Watanabe and Donald W. Bowden

Diabetes 2016 Jul; 65 (7): 2072-2080. https://doi.org/10.2337/db15-1543
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The Genetic Program of Pancreatic β-Cell Replication In Vivo
Agnes Klochendler, Inbal Caspi, Noa Corem, Maya Moran, Oriel Friedlich, Sharona Elgavish, Yuval Nevo, Aharon Helman, Benjamin Glaser, Amir Eden, Shalev Itzkovitz and Yuval Dor

Diabetes 2016 Jul; 65 (7): 2081-2093. https://doi.org/10.2337/db16-0003
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Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes
Kashyap A. Patel, Richard A. Oram, Sarah E. Flanagan, Elisa De Franco, Kevin Colclough, Maggie Shepherd, Sian Ellard, Michael N. Weedon and Andrew T. Hattersley

Diabetes 2016 Jul; 65 (7): 2094-2099. https://doi.org/10.2337/db15-1690

Erratum

Open Access
Erratum. The Effects of Type 2 Diabetes on Lipoprotein Composition and Arterial Stiffness in Male Youth. Diabetes 2013;62:2958–2967
Scott M. Gordon, W. Sean Davidson, Elaine M. Urbina, Lawrence M. Dolan, Anna Heink, Huaiyu Zang, L. Jason Lu and Amy S. Shah

Diabetes 2016 Jul; 65 (7): 2100. https://doi.org/10.2337/db16-er07

Issues and Events

Open Access
Issues and Events
Diabetes 2016 Jul; 65 (7): 2101. https://doi.org/10.2337/db16-ie07

e-Letters: Comments and Responses

Open Access
Comment on Salomon et al. Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation. Diabetes 2016;65:598–609
Rucha Patil, Kanjaksha Ghosh and Shrimati Shetty

Diabetes 2016 Jul; 65 (7): e24-e25. https://doi.org/10.2337/db16-0295
Open Access
Response to Comment on Salomon et al. Gestational Diabetes Mellitus Is Associated With Changes in the Concentration and Bioactivity of Placenta-Derived Exosomes in Maternal Circulation Across Gestation. Diabetes 2016;65:598–609
Carlos Salomon and Gregory E. Rice

Diabetes 2016 Jul; 65 (7): e26-e27. https://doi.org/10.2337/dbi16-0016

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Table of Contents

In This Issue

Perspectives in Diabetes

Commentaries

Diabetes Symposium: Bioactive Lipids and Nonpeptide Mediators of Metabolism

This section features three articles from the 3rd Diabetes Symposium held in conjunction with the ADA's 76th Scientific Sessions in New Orleans, LA, 10–14 June 2016.

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics/Genomes/Proteomics/Metabolomics

Erratum

Issues and Events

e-Letters: Comments and Responses

In this Issue

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