Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents
- Thomas Reinehr (T.Reinehr{at}kinderklinik-datteln.de)1,
- Anke Hinney2,
- Thuy Trang Nguyen3 and
- Johannes Hebebrand2
- 1: Vestische Hospital for Children and Adolescents, University of Witten/Herdecke
- 2: Department of Child and Adolescent Psychiatry; University of Duisburg-Essen, Essen
- 3: Institute of Medical Biometry and Epidemiology, Philipps-University of Marburg, Marburg, Germany
Abstract
Objective: Homozygotes for the C-allele of the single nucleotide polymorphism rs7566605 (SNP), which is located ∼10kb upstream of the insulin-induced gene 2 (INSIG2), showed a slightly increased risk to become obese. The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype.
Methods: We genotyped rs7566605 in 293 obese children (mean age 10.8y, 45% male, mean BMI 28.1 kg/m2) who presented for a one-year intervention. The reduction of SDS-BMI was compared based on an intention-to-treat analysis between the children with different genotypes. Blood pressure, triglyceride, total-, HDL- and LDL-cholesterol, insulin, and glucose concentrations were measured before and after intervention.
Results: After 1 year, obese children with the CC-genotype had reduced their SDS-BMI to a lower extent than obese children with GC- or GG- genotypes (recessive model p=0.007). There was no evidence for an association of rs7566605 with the cardiovascular risk factor profile (nominal p>0.1).
Conclusions: CC-homozygotes at SNP rs7566605 in the vicinity of INSIG2 lost less weight in this lifestyle intervention. This finding further implicates this polymorphism in weight regulation.
Footnotes
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- Received March 23, 2007.
- Accepted November 7, 2007.
- Copyright © American Diabetes Association
