Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes The Allegheny County Type 1 Diabetes Registry
- Aaron M. Secrest, PhD1,
- Dorothy J. Becker, MBBCh2,
- Sheryl F. Kelsey, PhD1,
- Ronald E. LaPorte, PhD1 and
- Trevor J. Orchard, MBBCh, MMedSci ()1
Objective: Little is known concerning the primary cause(s) of mortality in type 1 diabetes responsible for the excess mortality seen in this population.
Research Design and Methods: The Allegheny County (Pennsylvania) childhood-onset (age<18 yrs) type 1 diabetes registry (n=1,075) with diagnosis from 1965-79 was used to explore patterns in cause-specific mortality. Cause of death was determined by a mortality classification committee of at least 3 physician epidemiologists, based on the death certificate and additional records surrounding the death.
Results: Vital status for 1,043 (97%) participants was ascertained as of 1 January 2008, revealing 279 (26.0%) deaths overall (141 females and 138 males). Within the first 10 years after diagnosis, the leading cause of death was acute diabetes complications (73.6%), while during the next 10 years, deaths were nearly evenly attributed to acute (15%), cardiovascular (22%), renal (20%), or infectious (18%) causes. After 20 years duration, chronic diabetes complications (cardiovascular, renal, or infectious) accounted for >70% of all deaths, with cardiovascular disease as the leading cause of death (40%). Women (p<0.05) and African-Americans (p<0.001) have significantly higher diabetes-related mortality rates than men and Caucasians, respectively. SMRs for non-diabetes-related causes do not significantly differ from the general population (violent deaths: SMR=1.2, 0.6-1.8; cancer: SMR=1.2, 0.5-2.0).
Conclusions: The excess mortality seen in type 1 diabetes is almost entirely related to diabetes and its comorbidities, but varies by duration of diabetes and particularly affects women and African-Americans.
- Received June 21, 2010.
- Accepted August 11, 2010.
- Copyright © American Diabetes Association