Resting-State Brain Networks in Type 1 Diabetic Patients With and Without Microangiopathy and Their Relation to Cognitive Functions and Disease Variables
- Eelco van Duinkerken1,2⇓,
- Menno M. Schoonheim3,4,
- Ernesto J. Sanz-Arigita3,5,
- Richard G. IJzerman1,
- Annette C. Moll6,
- Frank J. Snoek2,
- Christopher M. Ryan7,
- Martin Klein2,
- Michaela Diamant1 and
- Frederik Barkhof3
- 1Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands
- 2Diabetes Psychology Research Group/Department of Medical Psychology, VU University Medical Center, Amsterdam, the Netherlands
- 3Department of Radiology, VU University Medical Center, Amsterdam, the Netherlands
- 4Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam, the Netherlands
- 5Department of Radiology, Centro de Investigación y Terapias Avanzadas (CITA)-Alzheimer Foundation, San Sebastian, Spain
- 6Department of Ophthalmology, VU University Medical Center, Amsterdam, the Netherlands
- 7Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
- Corresponding author: Eelco van Duinkerken, .
Cognitive functioning depends on intact brain networks that can be assessed with functional magnetic resonance imaging (fMRI) techniques. We hypothesized that cognitive decrements in type 1 diabetes mellitus (T1DM) are associated with alterations in resting-state neural connectivity and that these changes vary according to the degree of microangiopathy. T1DM patients with (MA+: n = 49) and without (MA−: n = 52) microangiopathy were compared with 48 healthy control subjects. All completed a neuropsychological assessment and resting-state fMRI. Networks were identified using multisubject independent component analysis; specific group differences within each network were analyzed using the dual-regression method, corrected for confounding factors and multiple comparisons. Relative to control subjects, MA− patients showed increased connectivity in networks involved in motor and visual processes, whereas MA+ patients showed decreased connectivity in networks involving attention, working memory, auditory and language processing, and motor and visual processes. Better information-processing speed and general cognitive ability were related to increased degree of connectivity. T1DM is associated with a functional reorganization of neural networks that varies, dependent on the presence or absence of microangiopathy.
- Received September 29, 2011.
- Accepted February 9, 2012.
- © 2012 by the American Diabetes Association.
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