Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes
Enteroviruses have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific enterovirus subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CBV) which has been linked to diabetes in previous surveys. Altogether 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, gender, age and country were recruited in Finland, Sweden, England, France and Greece during the years 2001-2005 (mean age 9 years; 55 % boys). Antibodies against CBV1 were more frequent among diabetic children than in control children (OR=1.7, 95%CI=1.0-2.9) while other CBV types did not differ between the groups. CBV1-associated risk was not related to HLA genotype, age or gender. Finnish children had lower frequency of CBV antibodies than children in other countries. The results support previous studies suggesting an association between group B coxsackieviruses and type 1 diabetes, highlighting the possible role of CBV1 as a diabetogenic virus type.
- Received April 18, 2013.
- Accepted July 31, 2013.
- © 2013 by the American Diabetes Association.
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