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Original Research
IRAK-M deficiency promotes the development of T1DM in NOD mice
Qiyuan Tan, Monika Majewska-Szczepanik, Xiaojun Zhang, Marian Szczepanik, Zhiguang Zhou, F Susan Wong and Li Wen
Diabetes 2014 Apr; DB_131504. https://doi.org/10.2337/db13-1504
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Abstract

Type 1 diabetes mellitus (T1DM) is an organ specific autoimmune disease characterized by progressive destruction of insulin-secreting pancreatic beta cells. Both T cell mediated adaptive responses, as well as innate immune processes are involved in pathogenesis. Interleukin-1 receptor associated kinase M (IRAK-M) can effectively inhibit the MyD88 downstream signals in TLR pathways, while lack of IRAK-M is known to be associated with autoimmunity. Our study showed that IRAK-M deficient (IRAK-M-/-) non obese diabetic (NOD) mice displayed early onset and rapid progression of T1DM with impaired glucose tolerance, more severe insulitis and increased serum anti-insulin auto-antibodies. Mechanistic studies showed that enhanced activation and antigen presenting function of IRAK-M deficient antigen presenting cells (APCs) from IRAK-M-/- mice were responsible for rapid progression of disease. Moreover, IRAK-M-/- dendritic cells (DCs) induced enhanced activation of diabetogenic T cells in vitro and rapid onset of T1DM in vivo in immunodeficient NOD mice when co-transferred with diabetogenic T cells. This study illustrates how modulation of innate immune pathways through IRAK-M influences the development of autoimmune diabetes.

  • Received October 1, 2013.
  • Accepted March 27, 2014.
  • © 2014 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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IRAK-M deficiency promotes the development of T1DM in NOD mice
Qiyuan Tan, Monika Majewska-Szczepanik, Xiaojun Zhang, Marian Szczepanik, Zhiguang Zhou, F Susan Wong, Li Wen
Diabetes Apr 2014, DB_131504; DOI: 10.2337/db13-1504

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IRAK-M deficiency promotes the development of T1DM in NOD mice
Qiyuan Tan, Monika Majewska-Szczepanik, Xiaojun Zhang, Marian Szczepanik, Zhiguang Zhou, F Susan Wong, Li Wen
Diabetes Apr 2014, DB_131504; DOI: 10.2337/db13-1504
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© 2019 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.