Cerebral microvascular lesions on High-Resolution 7T MRI in patients with type 2 diabetes
- Manon Brundel1⇑,
- Yael D. Reijmer1,
- Susanne J. van Veluw1,
- Hugo J. Kuijf2,
- Peter R. Luijten3,
- L. Jaap Kappelle1,
- Geert Jan Biessels1,
- on behalf of the Utrecht Vascular Cognitive Impairment (VCI) Study Group
- 1 Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, the Netherlands
- 2 Image Sciences Institute, University Medical Center Utrecht, the Netherlands
- 3 Department of Radiology, University Medical Center Utrecht, the Netherlands
- Corresponding author: Manon Brundel, E-mail:
Cerebral small vessel disease, including microvascular lesions, is considered to play an important role in the development of type 2 diabetes mellitus (T2DM) associated cognitive deficits. With ultra-high field MRI microvascular lesions (e.g. microinfarcts and microbleeds) can now be visualized in vivo. For the present study, 48 nondemented older individuals with T2DM (mean age 70.3±4.1 years) and 49 age-, sex-, and education-matched control subjects underwent a 7T brain MRI scan and a detailed cognitive assessment. The occurrence of cortical microinfarcts and cerebral microbleeds was assessed on FLAIR and T1-weighted images and T2*-weighted images respectively, compared between the groups and related to cognitive performance. Microinfarcts were found in 38% of controls and 48% of patients with T2DM. Microbleeds were present in 41% of control participants, and 33% of patients (all p>0.05). Presence and number of microinfarcts or microbleeds were unrelated to cognitive performance. This study showed that microvascular brain lesions on ultra-high field MRI are not significantly more common in well-controlled patients with T2DM than in controls.
- Received January 23, 2014.
- Accepted April 14, 2014.
- © 2014 by the American Diabetes Association.
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