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Original Research
Subclinical Disease in Subjects with Prediabetes, Diabetes and Normal Controls from the General Population: the KORA MRI-Study
Fabian Bamberg, Holger Hetterich, Susanne Rospleszcz, Roberto Lorbeer, Sigrid D. Auweter, Christopher L. Schlett, Anina Schafnitzel, Christian Bayerl, Andreas Schindler, Tobias Saam, Katharina Müller-Peltzer, Wieland Sommer, Tanja Zitzelsberger, Jürgen Machann, Michael Ingrisch, Sonja Selder, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Christian Weber, Birgit Ertl-Wagner, Steffen Massberg, Maximilian Reiser and Annette Peters
Diabetes 2016 Oct; db160630. https://doi.org/10.2337/db16-0630
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Abstract

Detailed pathophysiological manifestations of early disease in the context of prediabetes are poorly understood. This study aimed to evaluate the extent of early signs of cardiovascular complications affecting multiple organs in individuals with prediabetes. Subjects without prior history of stroke, coronary or peripheral artery disease were enrolled in a case-control study nested within the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and underwent comprehensive MR imaging assessment to characterize cerebral, (white matter lesions, microbleeds), cardiovascular (carotid plaque, left ventricular function and myocardial late gadolinium enhancement [LGE]), and metabolic parameters (hepatic proton-density-fat-fraction [PDFF] and subcutaneous and visceral adipose tissue). Among 400 subjects who underwent MRI, 103 subjects had prediabetes and 54 established diabetes. Subjects with prediabetes had an increased risk for carotid plaque and adverse functional cardiac parameters, including reduced early diastolic filling rates as well as a higher prevalence of LGE as compared to healthy controls. In addition, people with prediabetes had significantly elevated levels of PDFF and total and visceral adipose tissue. Thus, subjects with prediabetes show early signs of subclinical disease that include vascular, cardiac, and metabolic changes as measured by whole-body MRI after adjusting for cardiometabolic risk factors.

  • Received May 17, 2016.
  • Accepted October 4, 2016.
  • © 2016 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Subclinical Disease in Subjects with Prediabetes, Diabetes and Normal Controls from the General Population: the KORA MRI-Study
Fabian Bamberg, Holger Hetterich, Susanne Rospleszcz, Roberto Lorbeer, Sigrid D. Auweter, Christopher L. Schlett, Anina Schafnitzel, Christian Bayerl, Andreas Schindler, Tobias Saam, Katharina Müller-Peltzer, Wieland Sommer, Tanja Zitzelsberger, Jürgen Machann, Michael Ingrisch, Sonja Selder, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Christian Weber, Birgit Ertl-Wagner, Steffen Massberg, Maximilian Reiser, Annette Peters
Diabetes Oct 2016, db160630; DOI: 10.2337/db16-0630

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Subclinical Disease in Subjects with Prediabetes, Diabetes and Normal Controls from the General Population: the KORA MRI-Study
Fabian Bamberg, Holger Hetterich, Susanne Rospleszcz, Roberto Lorbeer, Sigrid D. Auweter, Christopher L. Schlett, Anina Schafnitzel, Christian Bayerl, Andreas Schindler, Tobias Saam, Katharina Müller-Peltzer, Wieland Sommer, Tanja Zitzelsberger, Jürgen Machann, Michael Ingrisch, Sonja Selder, Wolfgang Rathmann, Margit Heier, Birgit Linkohr, Christa Meisinger, Christian Weber, Birgit Ertl-Wagner, Steffen Massberg, Maximilian Reiser, Annette Peters
Diabetes Oct 2016, db160630; DOI: 10.2337/db16-0630
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© 2019 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.